Effects of different anesthesia methods on inflammatory factors and pain after total knee arthroplasty in patients with osteoarthritis
10.3760/cma.j.cn231583-20210823-00272
- VernacularTitle:不同麻醉方式对骨性关节炎患者全膝关节置换术后炎性因子及疼痛的影响
- Author:
Zifei CHENG
1
;
Xinying LI
;
He YANG
;
Yanhui YU
;
Hongkai SUN
;
Lihui ZHANG
Author Information
1. 呼伦贝尔市人民医院麻醉科 内蒙古民族大学呼伦贝尔临床医学院，呼伦贝尔 021008
- Keywords:
Osteoarthritis;
Combined spinal and epidural anesthesia;
Total knee arthroplasty;
Inflammatory factor;
Postoperative pain
- From:
Chinese Journal of Endemiology
2022;41(11):918-923
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effects of general anesthesia and combined spinal and epidural anesthesia on inflammatory factors and pain in patients with osteoarthritis after total knee arthroplasty.Methods:A total of 84 patients with osteoarthritis who underwent unilateral total knee arthroplasty in Hulunbuir People's Hospital from January 2020 to May 2021 were selected as the research subjects. They were randomly divided into general anesthesia group (40 cases) and combined spinal and epidural anesthesia group (44 cases). Venous blood samples of 5 ml were collected before operation and 6, 24, 48 hours after operation, and the contents of inflammatory factors [tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6] in serum were determined by enzyme-linked immunosorbent assay (ELISA). The visual analogue pain scale (VAS) of the two groups at 30 min, 6, 24 and 48 hours after operation was compared.Results:At 6 and 24 hours after operation, TNF-α, IL-1β and IL-6 levels in the combined spinal and epidural anesthesia group were lower than those in the general anesthesia group ( t = 4.17, 3.85, 8.95, 10.98, 10.04, 9.87, P < 0.05). There were significant differences in the levels of TNF-α, IL-1β and IL-6 at different time points between the general anesthesia group and combined spinal and epidural anesthesia group ( F = 271.67, 149.26, 81.70, 189.36, 102.44, 157.32, P < 0.001). At 6 and 24 hours after operation, the VAS scores of patients in the combined spinal and epidural anesthesia group were significantly lower than those in the general anesthesia group ( t = 6.60, 3.66, P < 0.05). There were statistically significant differences in VSA scores between the two groups at different time points ( F = 67.47, 52.37, P < 0.05). Conclusion:The effect of combined spinal and epidural anesthesia is significantly higher than general anesthesia in inhibiting the expression of TNF-α, IL-1β and IL-6 in patients with osteoarthritis after operation, and the effect of analgesia is obvious.
