Research progress of recombinant thioredoxin peroxidase of important human parasites involved in immunoregulation, immunodiagnosis and immunoprophylaxis
10.3760/cma.j.cn231583-20220112-00008
- VernacularTitle:人体重要寄生虫重组TPx参与免疫调控、免疫诊断及免疫预防的研究进展
- Author:
Wei HE
1
;
Bo LUO
;
Biying ZHOU
Author Information
1. 遵义医科大学寄生虫学教研室，遵义 563000
- Keywords:
Parasite;
Thioredoxin peroxidase;
Immunoregulation;
Immunodiagnosis;
Immunoprophylaxis
- From:
Chinese Journal of Endemiology
2022;41(10):856-860
- CountryChina
- Language:Chinese
-
Abstract:
Thioredoxin peroxidase (TPx) belongs to the superfamily of peroxiredoxins, which is widely expressed in various growth and development stages of parasites and their excretory secretions. On the one hand, recombinant TPx protein can participate in host immunoregulation; on the other hand, recombinant TPx protein has high sensitivity and specificity as a diagnostic antigen, and can be used for immunodiagnosis of parasitic diseases; in addition, it can also be used as a candidate vaccine molecule for the immunoprophylaxis of parasitic diseases. This paper reviews the research progress on host immunoregulation, immunodiagnosis and immunoprophylaxis by recombinant TPx protein of important human parasites.
