Research progress on the effect of fluorosis on nervous system and its mechanism
10.3760/cma.j.cn231583-20220118-00012
- VernacularTitle:氟中毒对神经系统影响及作用机制的研究进展
- Author:
Tengfei MAO
1
;
Xigong LI
;
Wenming PAN
;
Qin ZHANG
Author Information
1. 山西医科大学附属运城市中心医院骨科，运城 044000
- Keywords:
Fluorosis;
Central nervous system;
Autophagy;
Oxidative stress;
Apoptosis
- From:
Chinese Journal of Endemiology
2022;41(10):850-855
- CountryChina
- Language:Chinese
-
Abstract:
Fluorosis is an endemic disease caused by prolonged exposure to excessive fluoride and is considered a serious public health problem in many countries. In recent years, the damage of chronic fluorosis to the central nervous system has attracted extensive attention from scholars at home and abroad. The mechanisms of neurotoxicity caused by fluorosis include oxidative stress, inflammatory reaction, autophagy, neurotransmitters and related enzymes, changes in neural signaling pathways, abnormal neuronal energy metabolism of neurons, cell apoptosis, etc., causing permanent damage to human brain structure, impaired learning ability, memory dysfunction and behavioral problems. This article reviews the effects of fluorosis on the nervous system and related mechanisms, and provides a reliable basis for prevention and treatment of fluorosis.
