Neutrophil elastase:From mechanisms to therapeutic potential
- Author:
Weilin ZENG
1
;
Yingqiu SONG
;
Runze WANG
;
Rong HE
;
Tianlu WANG
Author Information
1. Department of Radiotherapy,Cancer Hospital of China Medical University,Liaoning Cancer Hospital and Institute,Shenyang,110000,China
- Keywords:
Neutrophil elastase;
Sivelestat;
COVID-19;
Pathophysiological mechanisms;
Therapeutic potential
- From:
Journal of Pharmaceutical Analysis
2023;13(4):355-366
- CountryChina
- Language:Chinese
-
Abstract:
Neutrophil elastase(NE),a major protease in the primary granules of neutrophils,is involved in microbicidal activity.NE is an important factor promoting inflammation,has bactericidal effects,and shortens the inflammatory process.NE also regulates tumor growth by promoting metastasis and tumor microenvironment remodeling.However,NE plays a role in killing tumors under certain conditions and promotes other diseases such as pulmonary ventilation dysfunction.Additionally,it plays a complex role in various physiological processes and mediates several diseases.Sivelestat,a specific NE inhibitor,has strong potential for clinical application,particularly in the treatment of coronavirus disease 2019(COVID-19).This review discusses the pathophysiological processes associated with NE and the potential clinical applications of sivelestat.
