Multimodal integrated strategy for the discovery and identification of quality markers in traditional Chinese medicine
- Author:
Xiaoyan LU
1
,
2
,
3
,
4
;
Yanyan JIN
;
Yuzhen WANG
;
Yunlong CHEN
;
Xiaohui FAN
Author Information
1. Pharmaceutical Informatics Institute,College of Pharmaceutical Sciences,Zhejiang University,Hangzhou,310058,China
2. Innovation Center in Zhejiang University,State Key Laboratory of Component-Based Chinese Medicine,Hangzhou,310058,China
3. Jinhua Institute of Zhejiang University,Jinhua,Zhejiang,321016,China
4. Westlake Laboratory of Life Sciences and Biomedicine,Hangzhou,310058,China
- Keywords:
Traditional Chinese medicine(TCM);
Quality marker(Q-marker);
Multimodal integrated strategy;
Quality control systems
- From:
Journal of Pharmaceutical Analysis
2022;12(5):701-710
- CountryChina
- Language:Chinese
-
Abstract:
With the modernization and internationalization of traditional Chinese medicine(TCM),the requirement for quality control has increased.The quality marker(Q-marker)is an important standard in this field and has been implemented with remarkable success in recent years.However,the establishment of Q-markers remains fragmented and the process lacks systematicity,resulting in inconsistent quality control and insufficient correlation with clinical efficacy and safety of TCM.This review introduces four multi-modal integrated approaches that contribute to the discovery of more comprehensive and accurate Q-markers,thus aiding in the establishment of new quality control patterns based on the characteristics and principles of TCM.These include the whole-process quality control strategy,chemical-activity-based screening method,efficacy,safety,and consistent combination strategy,and TCM theory-guided approach.Furthermore,methodologies and representative examples of these strategies are described,and important future directions and questions in this field are also proposed.
