Effects of HeNe laser combined with ultrashort wave therapy on pain factors and anti-inflammatory and pro-inflammatory factors in patients with chronic knee osteoarthritis
10.3760/cma.j.cn115455-20220507-00401
- VernacularTitle:HeNe激光联合超短波治疗对慢性膝骨关节炎患者疼痛因子及抗炎促炎因子的影响
- Author:
Wei WANG
1
;
Xiuliang LI
;
Di ZHANG
;
Jing CHEN
;
Wenxi LI
Author Information
1. 北京市西城区西长安街社区卫生服务中心全科诊室，北京 100031
- Keywords:
Laser;
Osteoarthritis, knee;
Ultrashort wave therapy;
Pain factor;
Anti-inflammatory proinflammatory factor
- From:
Chinese Journal of Postgraduates of Medicine
2023;46(1):30-35
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of HeNe laser combined with ultrashort wave therapy on pain factors, anti-inflammatory and pro-inflammatory factors in patients with chronic knee osteoarthritis (KOA).Methods:Using prospective research methods, 108 patients with chronic KOA in Xicheng District Xichang′an Street Community Health Service Center from January 2018 to December 2019 were selected as the research objects, and randomly divided into control group and observation group, with 54 cases in each group. The control group was given shortwave treatment, while the observation group was given HeNe laser combined with ultra-short wave treatment. The clinical efficacy, levels of pain factors, anti-inflammatory and pro-inflammatory factors and knee function were compared between the two groups, and the pain factors including prostaglandin E 2 (PGE 2), substance P (SP), dopamine (DA); the anti-inflammatory and pro-inflammatory factors including transforming growth factor β1 protein (TGF-β1), tumor necrosis factor-stimulating gene (TSG-6), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-1β (IL-1β). Results:The total effective rate of observation group was significantly higher than that of control group: 92.59% (50/54) vs. 75.93% (41/54), P<0.05. After treatment, the levels of PGE 2, SP, DA, TGF-β1, TSG-6, IL-10, TNF-α, IL-6 and IL-1β in the observation group were significantly lower than those in the control group: (2.50 ± 0.29) ng/L vs. (2.85 ± 0.32) ng/L, (1.55 ± 0.35) ng/L vs. (1.73 ± 0.36) ng/L, (12.46 ± 1.82) g/L vs. (15.25±2.20) g/L, (12.46 ± 2.06) μg/L vs. (15.58 ± 2.89) μg/L, (6.02 ± 0.89) ng/L vs. (6.84 ± 0.92) ng/L, (13.64 ± 2.92) ng/L vs. (16.50 ± 3.15) ng/L, (38.82 ± 7.15) ng/L vs. (47.05 ± 8.53) ng/L, (21.92 ± 4.19) ng/L vs. (25.41 ± 5.08) ng/L, (26.49 ± 6.74) ng/L vs. (31.53 ± 7.95) ng/L, P<0.05. After treatment, the levels of PGE2, SP, DA, TGF-β1, TSG-6, IL-10, TNF-α, IL-6 and IL-1β in the observation group were significantly lower than those in the control group ( P<0.05). The excellent rate of knee function in the observation group was significantly higher than that in the control group: 87.04% (47/54) vs. 64.81% (35/54), P<0.05. Conclusions:For patients with chronic KOA, HeNe laser combined with ultrashort wave therapy has better clinical efficacy, which can relieve pain, regulate the imbalance of body factors and improve the function of knee joint.
