The analysis on the correlation between CYP2C19 gene polymorphism and clopidogrel resistance in patients with acute coronary syndrome
10.3760/cma.j.cn115455-20210330-00452
- VernacularTitle:CYP2C19基因多态性与急性冠状动脉综合征患者氯吡格雷抵抗的相关性分析
- Author:
Xue ZHAO
1
;
Xuchen HAN
Author Information
1. 赤峰学院附属医院心内科，赤峰 024000
- Keywords:
Coronary disease;
Percutaneous coronary intervention;
Cytochrome P-450 CYP2C19;
Clopidogrel resistance
- From:
Chinese Journal of Postgraduates of Medicine
2022;45(12):1134-1137
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the relationship between CYP2C19 polymorphism and clopidogrel resistance (CR) in patients with acute coronary syndrome (ACS).Methods:One hundred and twenty-seven ACS patients treated with percutaneous coronary intervention (PCI) from June 2019 to June 2020 were enrolled, including 29 patients with CR(CR group) and 98 patients with none clopidogrel resistance (NCR, NCR group). The clinical data, coronary angiography results were compared between the two groups, the relationship of CYP2C19*2 and CYP2C19*3 polymorphisms and CR were analyzed.Results:The general data and coronary angiography between two groups had no significant differences ( P>0.05). There were differences in the distribution of isogenic genes and genotypes of CYP2C19 (rs4244285) and CYP2C19 (rs4986893) between the two groups ( P<0.05). Polymorphism of CYP2C19*2 and CYP2C19*3 was an important risk factor for CR ( OR = 14.688, 95% CI 3.652-59.063, P<0.01; OR = 7.228, 95% CI 2.412-21.663, P<0.01). Conclusions:CR is closely associated with CYP2C19*2 and CYP2C19*3 in ACS patients.
