Analysis of risk factors for patients with metastatic prostate cancer to progress to castration-resistant prostate cancer
10.3760/cma.j.cn115455-20210618-00803
- VernacularTitle:转移性前列腺癌患者进展为去势抵抗型前列腺癌的危险因素分析
- Author:
Le LIU
1
;
Chunqing FENG
;
Hongge ZHOU
Author Information
1. 沈阳医学院附属中心医院泌尿外科，沈阳 110024
- Keywords:
Prostatic neoplasms;
Neoplasm metastasis;
Castration-resistant prostate cancer;
Risk factors;
Retrospective studies
- From:
Chinese Journal of Postgraduates of Medicine
2022;45(12):1075-1079
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the risk factors for progression to castration-resistant prostate cancer (CRPC) in metastatic prostate cancer (mPCa) patients who underwent androgen deprivation therapy (ADT).Methods:One hunred mPCa patients underwent ADT were followed up from January 2014 to December 2020 in the Affiliated Central Hospital of Shenyang Medical University. Retrospective analyze the patient′s Gleason score, initial PSA value, minimum prostate specific antigen (nPSA) and time when PSA drops to the lowest point (TTN), and record the state of lymph node metastasis and bone metastasis. Single factor Kaplan-Meier analysis and multivariate Cox regression analysis were used to explore the related risk factors affecting the progress of CRPC.Results:A total of 82 cases (82%) of ADT patients progressed to CRPC. Univariate Kaplan-Meier analysis showed that Gleason score, PSA initial value, lowest nPSA and time to TTN, lymph node metastasis and bone metastasis are risk factors for CRPC ( P<0.01 or<0.05); Multivariate Cox regression analysis showed that Gleason score, initial PSA value, nPSA and TTN are independent risk factors for PCa patients to progress to CRPC ( P<0.01 or<0.05). Conclusions:This study demonstrated that Gleason score, lymph node metastasis, bone metastasis, initial PSA value, nPSA and TTN are risk factors for the progression of CRPC. Patients with higher Gleason grade, higher nPSA, shorter TTN, lymph node and bone metastasis have shorter PFS and higher risk of progression to CRPC.
