Research progress and prospect of metabonomics in glaucoma
10.3760/cma.j.cn115989-20200808-00572
- VernacularTitle:代谢组学在青光眼中的应用现状及展望
- Author:
Yunqing LU
1
;
Hua ZHONG
Author Information
1. 昆明医科大学第一附属医院眼科，昆明 650032
- Keywords:
Glaucoma;
Metabonomics;
Aqueous humor;
Mass spectrometry
- From:
Chinese Journal of Experimental Ophthalmology
2023;41(2):178-182
- CountryChina
- Language:Chinese
-
Abstract:
Metabonomics is an important component of systems biology.It reveals the essential metabolic characteristics of the activities of organisms using qualitative and quantitative detection and analysis of the dynamics of all endogenous low-molecular-weight metabolites within an organism before and after stimulation such as pathophysiological stimuli or genetic modification.Therefore, it provides insight into the pathogenesis, early diagnosis, treatment and prognosis of diseases.Metabonomics relies on chromatography, mass spectrometry, nuclear magnetic resonance spectroscopy and other analytical chemistry techniques to obtain data.The examination specimens are usually body fluids including blood, tear, aqueous humor and tissues such as trabecular meshwork, vitreous body, retina, etc.Glaucoma is an optic nerve disease characterized by optic disc damage and visual field defect.Previous animal and human studies have provided some preliminary results on metabolites associated with glaucoma.Metabonomics, genomics, transcriptomics, and proteomics constitute a bioinformatics system.Joint multi-omics research will be the direction of future development.On the basis of an overview of metabonomics, this paper reviewed the research progress of metabonomics in glaucoma based on different tissues and body fluid specimens.
