Comparison between endoscopic surgery and glucocorticoid therapy for traumatic optic neuropathy: a meta-analysis
10.3760/cma.j.cn115989-20201130-00809
- VernacularTitle:鼻内镜下手术与糖皮质激素药物治疗对外伤性视神经病变疗效比较的Meta分析
- Author:
Jinhai YU
1
;
Yan WU
;
Yaohua WANG
;
Qihua XU
;
Chao XIONG
;
Hongfei LIAO
Author Information
1. 南昌大学附属眼科医院眼眶病科 江西省眼科疾病临床医学研究中心 江西省眼科学与视觉科学研究所，南昌 330006
- Keywords:
Endoscopy;
Optic neuropathy, traumatic;
Hormone therapy;
Treatment outcome
- From:
Chinese Journal of Experimental Ophthalmology
2023;41(1):42-46
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To systematically analyze the efficacy of nasal endoscopic transsphenoidal decompression and glucocorticoid pulse therapy for traumatic optic neuropathy (TON).Methods:PubMed, Web of Science, Cochrane Library, ClinicalTrial.gov, CNKI, Wanfang, China Biomedical and other databases were searched to retrieve clinical studies on endoscopic surgery and hormone therapy for TON since their establishment to November 1, 2020.Two researchers screened the literature and evaluated the quality of the included literatures.The improvement of visual acuity before and after treatment was taken as an effective indicator.RevMan 5.3 statistical software was used for meta-analysis.The sensitivity of the results was analyzed atfer literature exclusion.The publication bias of each study was double checked by funnel plot and Begg test.Results:Eight studies were included, including 7 cohort studies and 1 randomized controlled trial.There was no significant difference between the endoscopic decompression group and glucocorticoid group in the efficiency of visual acuity improvement in the treatment of TON [odds ratio ( OR)=1.65, 95% confidence interval ( CI)∶0.75-3.66, P=0.22], neither in TON patients with residual vision before surgery ( OR=2.17, 95% CI: 0.94-4.98, P=0.07). For nasal endoscopic decompression surgery, early surgery (disease course<7 days) was more effective than late surgery (disease course>7 days) ( OR=4.73, 95% CI: 2.55-8.78, P<0.01). Sensitivity analysis suggested that the results of this literature analysis were not robust.The Begg test showed that there was no literature publication bias. Conclusions:There is no significant difference between nasal endoscopic surgery and glucocorticoid therapy in the treatment of TON.Early endoscopic surgery may help improve visual acuity in patients with residual vision.
