CD4 + Th cell associated cytokines and neuromyelitis optica spectrum disease
10.3760/cma.j.cn115989-20191104-00479
- VernacularTitle:CD4 + Th细胞相关性细胞因子与视神经脊髓炎谱系疾病
- Author:
Mengyu HAN
1
;
Zhijun WANG
;
Ming JIN
Author Information
1. 中日友好医院眼科，北京 100029
- Keywords:
Neuromyelitis optica;
Optic neuritis;
Cytokines;
Neuromyelitis optica spectrum disorders;
Th cells;
Interleukin
- From:
Chinese Journal of Experimental Ophthalmology
2022;40(12):1192-1196
- CountryChina
- Language:Chinese
-
Abstract:
Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune disease characterized by neuro-ophthalmic intercross and humoral immunity.Neuromyelitis optica related optic neuritis (NMO-ON) is often the initial symptom of NMOSD patients, with a high blinding rate, which brought a heavy blow to the quality of life, study, work and other aspects of patients.The discovery of aquaporin-4 immunoglobulin G (AQP4-IgG) has brought significant progress in the pathogenesis, diagnosis and treatment of NMOSD.However, AQP4-IgG is not a universal biomarker of NMOSD.The role of CD4 + T helper (Th) cell related cytokines in the pathogenesis of NMOSD has been increasingly emphasized.This paper reviewed the research results of CD4 + Th cell-related cytokines closely related to the occurrence of NMOSD in recent years, including Th17 cell-related cytokines such as interleukin-6 (IL-6), IL-17, IL-21, Th2 cell-related cytokines such as IL-4, IL-5, IL-13, IL-31, IL-33, and regulatory T cell-related cytokines, etc.to provide new insights for the pathogenesis, diagnosis and treatment strategies of NMOSD or NMO-ON.
