Short-term clinical outcomes of different courses of antenatal corticosteroids for preterm twins
10.3760/cma.j.issn.2096-2932.2023.09.005
- VernacularTitle:不同疗程产前糖皮质激素干预对双胎早产儿短期结局的影响
- Author:
Dongmei SUN
1
;
Zhiye QI
;
Qinghua ZHONG
;
Siyu LIU
;
Baowen FAN
;
Xiaoxiao TANG
;
Yi HE
;
Wanxin LI
;
Zhuoyi GAO
;
Yunbo XIE
;
Li YANG
;
Yue NING
;
Kun LIANG
;
Jiang DUAN
Author Information
1. 昆明医科大学第一附属医院儿童医学中心儿内科，昆明 650032
- Keywords:
Antenatal corticosteroids;
Neonatal respiratory distress syndrome;
Pregnancy, twin;
Premature birth
- From:Chinese Journal of Neonatology
2023;38(9):539-544
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the short-term clinical outcomes of different courses of antenatal corticosteroids (ACS) for preterm twins.Methods:From January 2017 to December 2021, preterm twins with gestational age (GA) 24-34 weeks admitted to the neonatal ward of our hospital and received ACS were retrospectively studied. The infants were assigned into single-course group, partial-course group and multiple-course group according to ACS courses. The short-term clinical outcomes were compared among the groups. SPSS software version 25.0 was used for statistical analysis.Results:A total of 286 infants were enrolled in this study, including 128 in single-course group, 89 in partial-course group and 69 in multiple-course group. Compared with single-course group, the risks of neonatal respiratory distress syndrome (RDS) in both partial-course group ( OR=2.332, 95% CI 1.028-5.293, P=0.043) and multiple-course group ( OR=3.872, 95% CI 1.104-13.584, P=0.034) were higher. The birth length in multiple-course group ( β=-0.016, 95% CI -0.029 - -0.002, P=0.024) was lower than single-course group. Conclusions:The risks of neonatal RDS in preterm twins are higher in partial-course and multiple-course of ACS. A full course of ACS should be used to prevent neonatal RDS until further evidence of effectiveness is available.
