Risk factors and clinical outcomes of early-onset pulmonary hypertension in preterm infants with gestational age≤ 32 weeks
10.3760/cma.j.issn.2096-2932.2023.06.002
- VernacularTitle:胎龄≤32周早产儿早期肺动脉高压危险因素及临床结局分析
- Author:
Xiangyun YIN
1
;
Min ZHAO
;
Liangliang LI
;
Hongmin XI
;
Ping YANG
;
Lili MA
;
Xianghong LI
Author Information
1. 青岛大学附属医院新生儿科，青岛 266000
- Keywords:
Pulmonary hypertension;
Bronchopulmonary dysplasia;
Premature infant
- From:Chinese Journal of Neonatology
2023;38(6):327-331
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the risk factors and clinical outcomes of early pulmonary hypertension in preterm infants with gestational age(GA)≤32 w.Methods:From October 2017 to May 2021,preterm infants with GA≤ 32 w admitted to NICU of our hospital were retrospectively studied. According to their echocardiography 2 w after birth, the infants were assigned into early-onset pulmonary hypertension (ePH) group and non-PH group. SPSS 21.0 statistical software was used to analyze the general status, complications and clinical outcomes of the two groups. Multiple logistic regression was used to analyze the risk factors of early-onset PH.Results:A total of 183 cases were enrolled, including 24 in the ePH group and 159 in the non-PH group. The incidences of birth asphyxia, hemodynamically significant patent ductus arteriosus (hsPDA), FiO 2≥30% within 6 h after birth, late-onset PH, severe bronchopulmonary dysplasia(BPD) and intracranial hemorrhage(ICH) in the ePH group were significantly higher than the non-PH group( P<0.05). hsPDA was the independent risk factor for early-onset PH ( OR=11.781, 95% CI 4.192-33.108). Conclusions:Preterm infants with GA≤32 w and early-onset PH are at increased risks of ICH, late-onset PH and severe BPD, hsPDA is the independent risk factor for early-onset PH.
