Clinical analysis of different types of neonatal sepsis: a multi-center retrospective study
10.3760/cma.j.issn.2096-2932.2023.05.001
- VernacularTitle:不同感染类型新生儿败血症的多中心回顾性临床分析
- Author:
Yuanqiang YU
1
;
Qingyi DONG
;
Suping LI
;
Huaxue QI
;
Xin TAN
;
Hong OUYANG
;
Jintao HU
;
Wen LI
;
Tao WANG
;
Yonghui YANG
;
Xiaoyun GONG
;
Xiaori HE
;
Pingyang CHEN
Author Information
1. 中南大学湘雅二医院儿童医学中心新生儿专科，长沙 410011
- Keywords:
Neonatal sepsis;
Clinical analysis;
Hospital-acquired infection;
Community-acquired infection
- From:Chinese Journal of Neonatology
2023;38(5):257-261
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the clinical characteristics of different types of neonatal sepsis.Methods:From January 2012 to December 2019, neonates with confirmed sepsis from 5 neonatal centers of central-south China were reviewed. The neonates were assigned into early-onset sepsis (EOS) and late-onset sepsis (LOS) group, and the latter was further subgrouped into hospital-acquired LOS (hLOS) group and community-acquired LOS (cLOS) group. The etiological and clinical characteristics were analyzed. SPSS 26.0 was used for statistical analysis.Results:A total of 580 neonates were enrolled, including 286 (49.3%) in the EOS group and 294 (50.7%) in the LOS group. In LOS group, 147 were in hLOS group and 147 were in cLOS group. The gestational age and birth weight of hLOS group were significantly lower than the other two groups [(32.7±3.6) weeks vs. (37.1±3.7) weeks and (37.7±3.0) weeks, (1 810±717) g vs. (2 837±865) g and (3 024±710) g] ( P<0.05). The common pathogens in EOS and cLOS groups were coagulase-negative staphylococci and Escherichia coli, while Klebsiella pneumoniae was common in hLOS group. Carbapenems usage in the hLOS group was significantly higher than the other two groups [62.6% vs. 28.7% and 16.2%] ( P<0.05). Antibiotics duration in the hLOS group was longer than the other two groups [19 (14, 27) d vs. 15 (12, 20) d and 14 (12, 19) d] ( P<0.05). Conclusions:The clinical characteristics of neonatal sepsis vary among different types of infections, and it is necessary to establish appropriate prevention, control, diagnosis and treatment protocols.
