Efficacy and safety of noninvasive high-frequency oscillatory ventilation in the treatment of respiratory distress syndrome in premature infants : a Meta-analysis
10.3760/cma.j.issn.2096-2932.2023.02.008
- VernacularTitle:无创高频振荡通气治疗早产儿呼吸窘迫综合征疗效及安全性的Meta分析
- Author:
Jiaqi ZHAO
1
;
Hua MEI
;
Yayu ZHANG
;
Yanbo ZHANG
;
Chun XIN
;
Yuheng ZHANG
;
Mengyue HUO
;
Xiaoli WANG
Author Information
1. 内蒙古医科大学附属医院新生儿科，呼和浩特 010050
- Keywords:
Respiratory distress syndrome;
Noninvasive high-frequency oscillatory ventilation;
Initial treatment;
Premature infant;
Meta analysis
- From:Chinese Journal of Neonatology
2023;38(2):101-106
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the efficacy and safety of noninvasive high-frequency oscillatory ventilation (nHFOV) as the initial ventilation mode for respiratory distress syndrome (RDS) in premature infants.Methods:From the establishment of the databases [(PubMed, Embase, Cochrane Library, CNKI, Wanfang database, CQVIP and CBM (SinoMed)] to March 1, 2022, literature on randomized controlled trials (RCTs) using nHFOV and nasal continuous positive airway pressure(NCPAP) as the initial ventilation modes for RDS in premature infants were searched. The qualities of the included literature were evaluated according to Cochrane Evaluation Manual. RevMan 5.4 software was used for Meta-analysis.Results:Seven RCTs involving 786 children were included for the final Meta-analysis, with 395 cases in the nHFOV group and 391 cases in the NCPAP group. The results showed that the nHFOV group had lower intubation rates than the NCPAP group ( OR=0.34, 95% CI 0.22~0.51, P<0.001). No significant differences existed in mortality rates and complication rates between the two groups ( P>0.05). Conclusions:nHFOV as the initial treatment for RDS in premature infants may reduce the incidence of early treatment failure without increasing complications.
