Risk factors of neonates with necrotizing enterocolitis require surgical therapy
10.3760/cma.j.issn.2096-2932.2023.01.007
- VernacularTitle:新生儿坏死性小肠结肠炎患儿需手术治疗的危险因素分析
- Author:
Weitao ZHONG
1
;
Tulian LIN
;
Jiale CHEN
;
Qiuming HE
;
Yan TIAN
;
Zuyi MA
;
Pengjian ZOU
;
Juan HE
;
Wei ZHONG
Author Information
1. 广州医科大学附属妇女儿童医疗中心新生儿外科监护室，广州 510623
- Keywords:
Necrotizing enterocolitis;
Surgical treatment;
Risk factors;
Early surveillance;
Newborn
- From:Chinese Journal of Neonatology
2023;38(1):29-33
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the risk factors of surgical therapy in neonates with necrotizing enterocolitis (NEC).Methods:From January 2016 to July 2020, neonates with a confirmed diagnosis of NEC (Bell's Stage Ⅱ and above) admitted to our hospital were retrospectively enrolled. They were assigned into surgical group and conservative group according to whether surgeries were performed. The conditions during perinatal period, clinical characteristics and laboratory examinations at the onset of NEC were compared between the two groups. Multivariate Logistic regression analysis was used to determine the risk factors of surgical therapy.Results:A total of 177 neonates with NEC were identified, including 62 cases (35.0%) in the surgical group and 115 cases (65.0%) in the conservative group. Multivariate Logistic regression analysis showed that male gender ( OR=3.178,95% CI 1.457~6.929, P=0.004), comorbidity with shock ( OR=3.434, 95% CI 1.112~10.607, P=0.032), mechanical ventilation>7 d before NEC onset ( OR=3.663, 95% CI 1.098~12.223, P=0.035) and lymphocytes <2.0×10 9/L ( OR=4.121, 95% CI 1.801~9.430, P=0.001) at the onset of NEC were independent risk factors for surgical therapy. Conclusions:Male gender, comorbidity with shock, mechanical ventilation >7 d before NEC and lymphocytopenia at the onset are independent risk factors for surgical therapy in neonates with NEC (Stage Ⅱ and above).
