The incidence and risk factors of early hyperglycemia in extremely preterm infants
10.3760/cma.j.issn.2096-2932.2023.01.005
- VernacularTitle:超早产儿早期高血糖症发生情况及危险因素分析
- Author:
Xiaofan SUN
1
;
Nan GU
;
Shuping HAN
;
Xiaohui CHEN
;
Qi WU
;
Jia CHENG
Author Information
1. 南京市妇幼保健院，南京医科大学附属妇产医院儿科，南京 210004
- Keywords:
Extremely preterm infants;
Extremely low birth weight infants;
Hyperglycemia;
Risk factors
- From:Chinese Journal of Neonatology
2023;38(1):18-22
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the incidence and risk factors of early hyperglycemia in extremely preterm infants (EPIs).Methods:From January 2018 to December 2021, EPIs with gestational age (GA) <28 w born in our hospital and admitted to the neonatal department were retrospectively studied. According to the occurrence of early hyperglycemia (within 1 w after birth), the infants were assigned into hyperglycemia group and non-hyperglycemia group. Univariate and logistic regression were used to analyze the risk factors of early hyperglycemia in EPIs.Results:A total of 218 cases of EPIs were enrolled, including 70 (32.1%) in the hyperglycemia group and 148 (67.9%) in the non-hyperglycemia group. The incidence of early hyperglycemia in EPIs with GA<25 w was 10/20 and 11/16 in EPIs with birth weight (BW) ≤700 g. The GA and BW of the hyperglycemia group were significantly lower than the non-hyperglycemia group ( P<0.05). More infants in the hyperglycemia group had 1-min and 5-min Apgar≤7 than the non-hyperglycemia group ( P<0.05). Logistic regression analysis showed that increased BW ( OR=0.995, 95% CI 0.993~0.997, P<0.05) was a protective factor for early hyperglycemia in EPIs, while male gender ( OR=2.512,95% CI 1.232~5.123, P<0.05), vasoactive drug use during the first week of life ( OR=2.687, 95% CI 1.126~6.414, P<0.05), maternal hypertension during pregnancy ( OR=14.735, 95% CI 1.578~137.585, P<0.05) were risk factors for early hyperglycaemia in EPIs. Conclusions:Early hyperglycemia are common among EPIs. Low BW, male gender, vasoactive drug use during the first week of life and maternal hypertension during pregnancy may increase the risk of early hyperglycemia.
