A Nationwide Survey of Inhalant Allergens Sensitization and Levels of Indoor Major Allergens in Korea.
10.4168/aair.2014.6.3.222
- Author:
Hye Jung PARK
1
;
Jae Hyun LEE
;
Kyung Hee PARK
;
Hea Won ANN
;
Moo Nyun JIN
;
Soo Young CHOI
;
Yong Won LEE
;
Chein Soo HONG
;
Jung Won PARK
Author Information
1. Division of Allergy and Immunology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. parkjw@yuhs.ac
- Publication Type:Original Article
- Keywords:
Allergen;
skin test;
dust;
indoor;
Korea
- MeSH:
Allergens*;
Animals;
Artemisia;
Asian Continental Ancestry Group;
Asthma;
Cockroaches;
Dander;
Dermatophagoides farinae;
Dogs;
Dust;
Enzyme-Linked Immunosorbent Assay;
Humans;
Humulus;
Inhalation;
Korea;
Nutrition Surveys;
Prevalence;
Pyroglyphidae;
Rhinitis;
Skin;
Skin Tests;
Viperidae;
Surveys and Questionnaires
- From:Allergy, Asthma & Immunology Research
2014;6(3):222-227
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: The higher prevalence of respiratory allergic disease may be due to increased exposure to inhalation allergens. We conducted a survey of allergic diseases in autumn and winter with detection of major indoor allergens in major cities in Korea. METHODS: We enrolled 110 subjects from the fourth Korea National Health and Nutrition Examination Survey with stratified, cluster, and systematic sampling procedures. All participants answered a health questionnaire as well as underwent a skin prick test (SPT) and ImmunoCAP for 11 indoor major allergens. We also measured the levels of 5 major allergens (Der f 1, Der p 1, Can f 1, Bla g 1, and Asp f 1) in fine indoor dust from the houses of 60 subjects with a 2-site ELISA. RESULTS: The prevalence of allergic rhinitis and asthma were 25.5% and 7.3%, respectively. The most common sensitized allergens identified by SPT and ImmunoCAP were Dermatophagoides farinae (40.9%, 36.8%), followed by cockroach (23.6%, 19.5%), mugwort (13.6%, 22.9%), oak (9.1%, 22.9%), Japanese hop (9.1%, 8.6%), and dog dander (8.2%, 6.9%). There was a modest discrepancy between SPT and ImmunoCAP. Der f 1 and Der p 1 were detected in 91.7% and 45.0% of the enrolled houses, respectively. Der f 1 indicated high concentrations in all specific provinces in Korea; however, Der p 1 measured high only in the south. Dog dander allergens were present in 71.7% of houses; however, Bla g 1 was present in only 11.7% of houses and Asp f 1 was not detected in any houses. CONCLUSIONS: The most important inhalant allergens in Korea are house dust mites followed by cockroach, mugwort, oak, Japanese hop, and dog dander in indoor environment, in which The dominant species of house dust mites were different according to region.
