'Oasis' in 'death desert': attach importance to the diagnosis and treatment for pancreatic cancer with microsatellite instability-high/deficient mismatch repair
10.3760/cma.j.cn115610-20230505-00194
- VernacularTitle:“死亡荒漠”的“绿洲”：重视微卫星高度不稳定/错配修复缺陷胰腺癌的诊断与治疗
- Author:
Yinmo YANG
1
;
Ruihan DONG
;
Xingsheng ZHANG
;
Yongsu MA
Author Information
1. 北京大学第一医院肝胆胰外科，北京 100034
- Keywords:
Pancreatic neoplasms;
Microsatellite instability-high;
Deficient mismatch repair;
Diagnosis;
Immunotherapy
- From:Chinese Journal of Digestive Surgery
2023;22(5):588-592
- CountryChina
- Language:Chinese
-
Abstract:
Pancreatic cancer (PC) is a malignant digestive tract tumor with poor prognosis. Most of patients with PC are insensitive to traditional strategies of chemotherapy, targeted therapy and immunotherapy. PC with microsatellite instability-high/deficient mismatch repair (MSI-H/dMMR) is rare in clinic, which has distinctive clinicopathological characteristics and better prognosis from conventional PC. Reasonable acquisition of pancreatic tumor biopsy and accurate assessment of MSI-H/dMMR status are helpful for accurate diagnosis of such patients. Individualized treatment strategy based on immunotherapy can significantly improve the prognosis of patients with MSI-H/dMMR PC. Based on relevant literatures of domestic and foreign, the authors discuss the current status and research hotspots of diagnosis and treatment for MSI-H/dMMR PC.
