Gut microbiota and neonatal necrotizing enterocolitis
10.3760/cma.j.issn.1673-4912.2023.02.003
- VernacularTitle:肠道微生态与新生儿坏死性小肠结肠炎
- Author:
Tian SANG
1
;
Ying WANG
Author Information
1. 北京大学第一医院儿科 100034
- Keywords:
Gut microbiota;
Necrotizing enterocolitis;
Premature infants
- From:
Chinese Pediatric Emergency Medicine
2023;30(2):90-97
- CountryChina
- Language:Chinese
-
Abstract:
The pathophysiology of neonatal necrotizing enterocolitis (NEC) is not clear, but is considered to be multifactorial.Immaturity of the gut, hypoxia-ischemia, formula feeding and microbial dysbiosis play roles in inducing intestinal inflammatory response.This review discussed the development process of infant gut microbiota, the factors affecting neonatal intestinal colonization, the roles of gut microbiome in the pathogenesis of NEC, and the manifestations of early microecology disorder in NEC.In addition, studies on the use of probiotics to prevent NEC and the risks of using probiotics in preterm infants were also summarized.
