Research progress on interleukin-10 receptor A in the pathogenesis of inflammatory bowel disease
10.3760/cma.j.issn.1673-4912.2022.12.014
- VernacularTitle:白细胞介素10受体A在炎症性肠病发病机制中的研究进展
- Author:
Yiyun XIONG
1
;
Lingfen XU
Author Information
1. 中国医科大学附属盛京医院小儿消化内科，沈阳 110004
- Keywords:
Inflammatory bowel disease;
Interleukin-10 receptor A;
Intestinal barrier;
Immune;
Heredity
- From:
Chinese Pediatric Emergency Medicine
2022;29(12):1003-1006
- CountryChina
- Language:Chinese
-
Abstract:
Inflammatory bowel disease(IBD) is a complex multifactorial disease characterized by chronic recurrent intestinal inflammation.The etiology of IBD has not yet been determined, and relevant studies have focused on the genetic susceptibility, immune response, intestinal microbiome and environmental factors of the host.Studies have found that interleukin-10 receptor A(IL-10RA)plays important roles in the pathogenesis of IBD.IL-10RA can not only affect the intestinal barrier, but also affect the intestinal immune system.Furthermore, the mutation of IL-10RA itself is highly correlated with very early-onset IBD.
