Research progress of familial primary nocturnal enuresis

VernacularTitle:家族性原发性遗尿症研究进展
Author: Yakai LIU ¹ ; Huijie HU ; Cuiping SONG ; Jianguo WEN
Author Information

1. 新乡医学院第一附属医院小儿外科，卫辉　453100
Keywords: Enuresis; Family history; Gene
From: Chinese Journal of Applied Clinical Pediatrics 2023;38(8):636-640
CountryChina
Language:Chinese
Abstract: Familial primary nocturnal enuresis (FPNE) is common in clinical practice and has shown an obvious familial aggregation that is associated with genetic factors.It has been found that chromosomes 4, 8, 12, 13 and 22 are related to the inheritance of enuresis. PRDM13 and EDNRB genes are related to the pathogenesis of enuresis, but the specific functions remain unclear.FPNE accounts for a high proportion in patients with refractory enuresis.Compared with other types of primary enuresis, FPNE is not difficult to be diagnosed, as long as the related family members have enuresis, it can be diagnosed as FPNE.Due to treatment difficulties, FPNE easily lasts into adulthood, serving as a type of intractable enuresis.Therefore, early diagnosis and active intervention should be made for children with FPNE.In this review, the epidemiology, pathogenesis, diagnosis and treatment of FPNE were summarized, aiming to provide references for improving the clinical diagnosis and treatment of FPNE.