Research progress on the pathogenesis of attention deficit hyperactivity disorder based on the theory of Dopamine deficits
10.3760/cma.j.cn101070-20220521-00584
- VernacularTitle:基于多巴胺缺陷理论的注意缺陷多动障碍发病机制研究
- Author:
Rongyi ZHOU
1
;
Bingxiang MA
;
Yongting ZHANG
;
Xinyue XIE
;
Chenlei WU
;
Xueying DING
Author Information
1. 河南中医药大学第一附属医院儿童脑病诊疗康复中心，郑州 450000
- Keywords:
Attention deficit hyperactivity disorder;
Dopamine deficit theory;
Dopamine transporter;
Enzymatic inactivation;
Dopamine receptor
- From:
Chinese Journal of Applied Clinical Pediatrics
2023;38(8):623-628
- CountryChina
- Language:Chinese
-
Abstract:
Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder in childhood, which seriously affects physical and mental health in children.Its etiology and pathogenesis are complex and have not been fully elucidated.Currently, the theory of Dopamine (DA) deficits has been widely recognized and studied in the international academic community.The DA system is considered as the key to the pathogenesis of ADHD.The causes of DA deficits are complex.In addition to the well-established reuptake disorder caused by abnormal DA transporter function, DA deficits are also associated with the activation of DA vesicle cycle enzymatic inactivation, vesicle transport dysfunction, and receptor dysfunction, which are of great significance in analyzing disease pathogenesis and drug development.This article reviews the research on the causes of DA deficits proposed in recent years based on the theory of DA deficits, aiming to provide ideas and references for the research on the pathogenesis of ADHD in China.
