Research progress on the correlation between early life adversity and the puberty initiation
10.3760/cma.j.cn101070-20220421-00439
- VernacularTitle:生命早期逆境与青春期启动关联的研究进展
- Author:
Guijiao ZHANG
1
;
Wei WU
Author Information
1. 华中科技大学同济医学院附属同济医院儿科，武汉 430030
- Keywords:
Exposure in early life;
Nutrition;
Endocrine disrupting chemicals;
Puberty initiation;
Neuroendocrine mechanism
- From:
Chinese Journal of Applied Clinical Pediatrics
2023;38(7):557-560
- CountryChina
- Language:Chinese
-
Abstract:
Earlier onset of puberty has become a worldwide trend.A large number of epidemiologic and animal experiment evidences have indicated that environmental changes in the early life may influence development plasticity and cause structural and functional changes, which are correlated with adult chronic diseases.The impact of fluctuations in environmental factors on the reproductive phenotype of offspring has been well concerned in recent years.This review summarizes the influences of nutritional state, endocrine disrupting chemicals, hormonal perturbation and stressful events during the prenatal and early childhood on the puberty initiation, especially neuroendocrine changes in puberty, thus providing a new idea for the prevention and control of pubertal disorders.
