Quality of life in children with McCune-Albright syndrome and its influencing factors
10.3760/cma.j.cn101070-20221108-01278
- VernacularTitle:McCune-Albright综合征患儿生活质量及其影响因素分析
- Author:
Huimin HAO
1
;
Minli DING
;
Xiaocui MA
;
Yanan GUO
;
Yongxing CHEN
;
Chang SU
;
Haiyan WEI
Author Information
1. 郑州大学附属儿童医院，河南省儿童医院，郑州儿童医院内分泌遗传代谢科，河南省遗传代谢重点实验室，郑州 450000
- Keywords:
Child;
McCune-Albright syndrome;
Quality of life
- From:
Chinese Journal of Applied Clinical Pediatrics
2023;38(7):528-531
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the quality of life in children with McCune-Albright syndrome (MAS) and its influencing factors, so as to provide scientific basis for improving their quality of life.Methods:The clinical data of 31 children with MAS diagnosed (MAS group) and followed up in Henan Children′s Hospital from June 2015 to December 2021 were retrospectively analyzed.During the same period, 37 healthy age and sex-matched children at a ratio of 1∶1 were recruited as healthy control group.The children′s Quality of Life Universal Core Scale (PedsQL?4.0) was used for the investigation and comparative analysis.Statistical analysis was performed using the independent sample t test, Chi- square test and multiple regression analysis. Results:Compared with the healthy control group, the physiological function ( t=2.092, P<0.05), emotional function ( t=2.373, P<0.05) and total score ( t=2.360, P<0.05) of MAS group significantly decreased.Multiple regression analysis showed that physiological function was negatively correlated with the annual number of vaginal bleeding ( t=-2.367, P<0.05) and the age of first fracture ( t=-2.606, P<0.05). Social function was negatively correlated with the number of fractures ( t=-2.481, P<0.05). Conclusions:The overall quality of life of MAS children is low, especially the quality of physiological function and emotional function.The annual number of vaginal bleedings, the age of the first fracture and the number of fractures are influencing factors for the reduction of the quality of life of children with MAS.
