Research advance on the role of hypoxia-inducible factor-1 in oxygen-induced retinal neovascularization
10.3760/cma.j.cn101070-20211103-01305
- VernacularTitle:低氧诱导因子-1在氧诱导视网膜新生血管形成中的研究进展
- Author:
Wanwan FAN
1
;
Xianqiong LUO
Author Information
1. 广东省妇幼保健院新生儿科，广州 511442
- Keywords:
Hypoxia-inducible factor-1;
Retinopathy of prematurity;
Oxygen-induced retinal neovascularization
- From:
Chinese Journal of Applied Clinical Pediatrics
2023;38(3):230-233
- CountryChina
- Language:Chinese
-
Abstract:
Hypoxia-inducible factor-1 (HIF-1) is an essential transcription factor, which mediates the transcription of multiple target genes to adapt the body for hypoxia.Oxygen-induced retinal neovascularization (RNV) is an important pathological process of retinopathy of prematurity (ROP). By mediating the transcription of vascular endothelial growth factors, angiopoietin and platelet-derived growth factors, HIF-1 can promote RNV and then lead to ROP.Therefore, HIF-1 plays a vital role in the pathological process of ROP.In this paper, the recent research progress on the role of HIF-1 in oxygen-induced RNV was summarized in order to further the understanding of ROP pathogenesis and treatment.
