Research progress of pyroptosis in the treatment of gastric cancer
10.3760/cma.j.cn.115807-20221002-00268
- VernacularTitle:细胞焦亡在胃癌治疗中的研究进展
- Author:
Zihan ZHOU
1
;
Yue ZHOU
;
Xuhua YING
Author Information
1. 浙江中医药大学第二临床医学院，杭州 310053
- Keywords:
Pyroptosis;
Gastric cancer;
Programmed cell death
- From:
Chinese Journal of Endocrine Surgery
2023;17(3):367-369
- CountryChina
- Language:Chinese
-
Abstract:
Pyroptosis belongs to the programmed cell death of inflammatory cells, which is regulated by GSDMD (Caspase-1,-4,-5-11) and GSDME (Caspase-3, granzyme). Multiple regulatory pathways of pyroptosis are abnormally expressed in gastric cancer cells, indicating that pyroptosis is closely related to gastric cancer and has the potential to become a new target for gastric cancer treatment. Combined with current mainstream treatments such as chemotherapy and immunotherapy, it may improve clinical treatment effect of gastric cancer. This article reviews the molecular mechanism of pyroptosis, the related research on gastric cancer and pyroptosis, and the related research on pyroptosis and gastric cancer treatment to explore the possibility of pyroptosis as a new target for gastric cancer, and to provide new research ideas for gastric cancer treatment.
