Progress of research on oncogene PTEN in thyroid malignant tumors

VernacularTitle:PTEN在甲状腺恶性肿瘤中的研究进展
Author: Fan LIU ¹ ; Panlong WANG ; Yalan ZHANG ; Yahui CHAI ; Ailin SONG
Author Information

1. 兰州大学第二医院普外科，兰州　730030
Keywords: PTEN; Oncogenes; Thyroid malignant tumors
From: Chinese Journal of Endocrine Surgery 2023;17(3):364-366
CountryChina
Language:Chinese
Abstract: The phosphatase and tensin homolog deleted on chromosome ten (PTEN) is a common oncogene located in the 10q23.3 region on the long arm of human chromosome l0, which regulates a variety of biological processes such as proliferation, survival, cell structure, motility, energy metabolism and genomic stability. Inactivation of PTEN is prevalent in almost all malignancies and correlates with tumor progression. Thyroid malignancies are among the most common endocrine malignancies, and PTEN has been shown to be critically associated with their development. The aim of this review is to describe the structural function of PTEN, as well as to summarize and discuss the recent findings of PTEN in thyroid malignancies.