Effects of Long-term Intermittent Oxygen Administration on the Cognitive Function in Rats.
10.4097/kjae.2007.52.6.687
- Author:
Seung Lyong KOO
1
;
Chul Hyun KIM
;
Hae Chul AHN
;
Dong Won KIM
;
Kyoung Hun KIM
;
Chan KIM
Author Information
1. Department of Anesthesiology and Pain Medicine, College of Medicine, Hanyang University, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
cognitive function;
long-term oxygen administration;
water maze
- MeSH:
Animals;
Oxygen*;
Rats*;
Rats, Sprague-Dawley
- From:Korean Journal of Anesthesiology
2007;52(6):687-693
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Several studies have demonstrated that the transient administration of oxygen improves cognitive performance. However, the effect of long-term oxygen administration remains unknown. This study investigated the impact of long-term oxygen administration on cognitive enhancement. METHODS: Six week old Sprague-Dawley rats (n = 46) were randomly allocated to one of three groups: the control (Control; n = 15), 30 min/day oxygen administration (Oxy30min; n = 16) and 60 min/day oxygen administration groups (Oxy60min; n = 15). The rats in all three groups were administered air or oxygen for 10 weeks. The Morris water maze test was employed to assess the latency (L & Lt), dwelling time (DT) and the total fraction above the mean dwelling time (FmDT) for cognitive performance. RESULTS: Compared to the control group, the Oxy30min and Oxy60min groups showed no differences in their L and Lt. There was a dose-response trend due to oxygen administration. Compared to the control group, the Oxy60min group had a significantly improved DT (P< 0.05). The FmDT also significantly increased in both of the oxygen administration groups, which also showed a dose-response trend (P<0.05). CONCLUSIONS: The present results suggest that long-term (10 weeks) oxygen administration can dose-dependently enhance cognitive performance.
