Concern about the prevention and treatment of parathyroid hyperfunction or hyperparathyroidism associated metastatic vascular calcification or calcinosis universalis
10.3760/cma.j.cn.115807-20221212-00370
- VernacularTitle:关注甲状旁腺功能增强或亢进相关转移性血管钙化和全身迁徙性钙质沉着症的防治
- Author:
Lingquan KONG
1
;
Baiqing PENG
;
Zhaoxing LI
;
Xiuquan QU
;
Fan LI
;
Hongyuan LI
;
Kainan WU
Author Information
1. 重庆医科大学附属第一医院乳腺甲状腺外科，重庆 400016
- Keywords:
Parathyroid hyperfunction;
Hyperparathyroidism;
Calcium and/or vitamin D insufficiency;
Metastatic vascular calcification;
Calcinosis universalis;
Osteopor
- From:
Chinese Journal of Endocrine Surgery
2023;17(1):1-4
- CountryChina
- Language:Chinese
-
Abstract:
Metastatic vascular calcification and calcinosis universalis, as severe complications of parathyroid hyperfunction and hyperparathyroidism, have attracted more attention in patients with renal secondary hyperparathyroidism and primary hyperparathyroidism. But, they are of little concern in patients with long-term negative calcium balance related parathyroid hyperfunction or hyperparathyroidism caused by calcium and/or vitamin D insufficiency (CVI). CVI is common in the population. Relatively low level of serum calcium and negative calcium balance caused by long-term CVI result in parathyroid hyperfunction or hyperparathyroidism, which may cause secretion of PTH beyond the physiological level, leading to bone absorption and release of a large amount of bone calcium into the blood. It may not only cause bone loss and osteoporosis, but also form metastatic vascular calcification or calcinosis universalis presented by cardiovascular diseases and other multi-organ lesions. Early calcium deposition can gradually fade after reasonable treatment, but middle arterial calcification is not easy to fade once it occurs. Therefore, vascular calcification and calcium deposition should be actively prevented and early screened and diagnosed. The early prevention, diagnosis and treatment of parathyroid hyperfunction or hyperparathyroidism can prevent, delay, or even reverse the occurrence and development of metastatic vascular calcification and calcinosis universalis, which is significant for disease prevention and protecting the patients' health influenced by these diseases.
