Analysis of etiology distribution and clinical manifestation in bilateral adrenal lesions
10.3760/cma.j.cn.115807-20200616-00188
- VernacularTitle:双侧肾上腺病变的病因分布谱及临床表现分析
- Author:
Jiale SHI
1
;
Qin YANG
;
Qinglian ZENG
;
Yingxiao ZHANG
;
Qingfeng CHENG
;
Zhipeng DU
Author Information
1. 重庆医科大学附属第一医院内分泌科，重庆 400016
- Keywords:
Adrenal gland neoplasm;
Cushing’s syndrome;
Primary aldosteronism;
Pheochromocytoma
- From:
Chinese Journal of Endocrine Surgery
2022;16(6):685-688
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the etiologies and clinical characteristics of bilateral adrenal lesions.Methods:The clinical data of 143 patients with bilateral adrenal lesions hospitalized in the First Affiliated Hospital of Chongqing Medical University from Jan. 2013 to Mar. 2018 were collected and analyzed.Results:140 patients were retained for final analysis. 79 were men, and 61 were women. The age was (51.53±13.93) years. Regarding the etiologies, there were primary aldosteronism ( n=44, 31.43%) , Cushing’s syndrome ( n=27, 19.29%) , non-functional lesions ( n=23, 16.43%) , adrenal tuberculosis ( n=17, 12.14%) , pheochromocytoma ( n=11, 7.86%) , congenital adrenal hyperplasia ( n=5, 3.57%) , adrenal metastases ( n=5, 3.57%) , and adrenal lymphoma ( n=4, 2.86) . These patients were classified into the following groups according to the mass size: ≤2 cm, 2-4 cm and ≥4 cm. The highest proportion of primary aldosteronism (62.79%) , Cushing’s syndrome (46.15%) and pheochromocytoma (31.25%) was observed in the ≤2 cm, 2-4 cm and ≥4 cm groups, respectively. The mass sizes of primary aldosteronism, Cushing’s syndrome and pheochromocytoma were compared, with pheochromocytoma the largest, followed by Cushing’s syndrome, non-functional lesion, and primary aldosteronism. Conclusions:For patients with bilateral adrenal lesions in our hospital, primary aldosteronism and Cushing’s syndrome are more common than non-functional lesion. Mass size is of great value in the diagnosis of endocrinological etiology, as well as distinguishing malignant tumors from the benign ones. The imaging phenotype is helpful to determine tumor types.
