A clinical research on relationship between sepsis-induced coagulopathy and prognosis in patients with sepsis
10.3760/cma.j.issn.1671-0282.2023.06.011
- VernacularTitle:脓毒症诱导凝血功能障碍对脓毒症患者预后的评估价值
- Author:
Weimin ZHU
1
;
Danhong HUANG
;
Qiaohong WANG
;
Bingbing BIAN
;
Ping LI
;
Peng YANG
;
Renfei SHAN
;
Chao ZHANG
;
Yinghe XU
;
Xiaxia HE
;
Yongpo JIANG
Author Information
1. 浙江省台州医院急诊科，台州 318050
- Keywords:
Sepsis;
Sepsis-induced coagulopathy;
Platelet count;
International normalized ratio;
Sequential organ failure assessment score;
Acute physiology and chroni
- From:
Chinese Journal of Emergency Medicine
2023;32(6):781-786
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the prognostic value of sepsis-induced coagulopathy (SIC) in patients with sepsis.Methods:From January 2019 to December 2021, patients with sepsis admitted to the Intensive Care Unit of our hospital were retrospectively classified into the SIC group and non-SIC group according to SIC diagnostic criteria. The baseline clinical data, severity score, total length of hospital stay, length of ICU stay and 28-day survival were compared between the two groups. Kaplan-Meier was used to compare the 28-day survival of patients with sepsis between the two groups. Cox proportional hazard regression model was employed to analyze the risk factors of prognosis in patients with sepsis.Results:Totally 274 patients with sepsis were included in the analysis, including 139 patients in the SIC group and 135 patients in the non-SIC group. The two groups were compared in the perspectives of the Platelet count (PLT), prothrombin time (PT) , procalcitonin (PCT), D dimer, hematocrit, red blood cell distribution width, hemoglobin, acute kidney injury (AKI), the use of continuous renal replacement treatment (CRRT), the use of vasoactive drugs, sequential organ failure assessment (SOFA) score, acute physiology and chronic health evaluation (APACHEⅡ) score were compared between the two groups and the difference were statistically different (all P<0.05). Kaplan-Meier analysis showed that the 28-day mortality rate in the SIC group was significantly higher than that in the non-SIC group (32.4% vs. 14.1%, P<0.05). COX proportional hazard model showed that SIC score ( HR= 2.17, 95% CI: 1.15-3.91, P<0.05), APACHEⅡ score ( HR= 1.13, 95% CI: 1.09-1.17, P<0.05) and the use of vasoactive drugs ( HR=3.66, 95% CI: 1.53-8.75, P<0.05) were independent influencing factors for 28-day death in patients with sepsis. Conclusions:Patients with sepsis and SIC have more severe disease and increased mortality risk. SIC score exhibits good clinical value in predicting the prognosis of patients with sepsis.
