Correlation analysis of apparent diffusion coefficient combined with C-reactive protein on delayed encephalopathy caused by carbon monoxide poisoning
10.3760/cma.j.issn.1671-0282.2023.03.009
- VernacularTitle:表观扩散系数联合C-反应蛋白对一氧化碳中毒迟发性脑病的相关性分析
- Author:
Chen LI
1
;
Min WANG
;
Menglin LIANG
;
Yanyun GUAN
;
Lingling LIU
;
Wei ZHANG
;
Yubo LIU
;
Jiarui XU
;
Baobao FENG
;
Xingguo ZHANG
Author Information
1. 山东第一医科大学附属省立医院中毒与职业病科，济南 250021
- Keywords:
Poisoning;
Delayed encephalopathy after carbon monoxide poisoning;
C-reactive protein;
Inflammatory markers;
Apparent diffusion coefficient
- From:
Chinese Journal of Emergency Medicine
2023;32(3):327-331
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the Correlation between ADC combined with serum C-reactive protein (CRP) and delayed encephalopathy after carbon monoxide poisoning (DEACMP), It provides scientific basis for early prediction of DEACMP.Methods:According to the design principle of case-control study, the data of acute carbon monoxide poisoning (ACOP) patients admitted to Shandong Provincial Hospital from December 2017 to December 2021 were retrospectively selected. Among them, patients with DEACMP were selected as the case group, without DEACMP were used as the control group. Univariate and multivariate analyses were performed on the two groups. Receiver operating characteristic curve (ROC) was used to evaluate the diagnostic efficacy of ADC combined with CRP as a combined predictor for disease.Results:A total of 89 patients with ACOP were included, including 33 patients with DEACMP and 56 patients without DEACMP. There were no significant differences in gender, age, smoking, drinking, and underlying diseases (hypertension, coronary heart disease) between groups ( P>0.05). Logistic regression analysis showed that white blood cell count (WBC) ( OR=1.64, 95% CI: 1.19-2.26, P=0.003), CRP ( OR=1.22, 95% CI: 1.03-1.45, P=0.019) and ADC value of central semiovale white matter ( OR=0.99, 95% CI: 0.98-1.00, P=0.010) were associated with DEACMP in patients with ACOP. The ROC curve results showed that the area under the ROC of ADC combined with CRP in the center of semiovale was 0.765 (95% CI: 0.656-0.845), the specificity was 87.9%, the sensitivity was 23.2%, and the cut-off value was 3.5°. Conclusions:WBC, CRP and ADC value of central semiovale are independent factors for DEACMP. ADC value of central semiovale combined with CRP has more clinical value in the early diagnosis of DEACMP. For ACOP patients with DEACMP triggering factors, the diagnosis and treatment awareness of early screening of brain magnetic resonance imaging should be strengthened to avoid DEACMP.
