Clinical value of sodium dithionite reduction method in the diagnosis and treatment of diquat poisoning
10.3760/cma.j.issn.1671-0282.2023.02.011
- VernacularTitle:连二亚硫酸钠还原法在敌草快中毒诊疗中的临床价值
- Author:
Jinquan LI
1
;
Zhengsheng MAO
;
Jinsong ZHANG
;
Zihao WANG
;
Yuxuan WU
;
Lili JIANG
;
Feng CHEN
;
Hao SUN
Author Information
1. 南京医科大学第一附属医院急诊医学科，南京 210029
- Keywords:
Diquat;
Poisoning;
Sodium dithionite reduction method;
Rapid detection;
Prognosis
- From:
Chinese Journal of Emergency Medicine
2023;32(2):192-197
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the clinical value of urine semi-quantitative colorimetry by sodium dithionite reduction method in the diagnosis and treatment of diquat poisoning.Methods:The data of 49 patients with acute diquat poisoning treated in the First Affiliated Hospital of Nanjing Medical University from December 3, 2020 to November 23, 2022 were retrospectively analyzed, the correlation between urine colorimetric results and plasma diquat concentration was observed, and the predictive value of urine colorimetric results for target organ damage and prognosis were evaluated.Results:There was a significant correlation between urine colorimetric results and plasma diquat concentration, the correlation coefficient was r=0.89, P <0.01. The cut-off value of urine colorimetry for the predicting the damage of gastrointestinal tract, liver, kidney, and central nervous system injury were 2.5, 3.5, 3.5, 5.5, respectively; in which the urine colorimetric results showed the highest sensitivity in predicting digestive tract injury [ AUC 0.93 (95% CI:0.89-1.00)]. The cut-off value of urine colorimetry for the prognosis of death was 4.5, the positive predictive value was 64.2%, and the negative predictive value was 95.2%. Conclusions:The urine semi-quantitative method can be used for rapid prediction of the plasma diquat concentration range on admission. The urine colorimetry results can also effectively predict the occurrence of organ injury and clinical outcome related to diquat poisoning, which provides evidence for the clinical diagnosis and therapy.
