Historical control data from 13-week repeated toxicity studies in Crj:CD (SD) rats.
10.5625/lar.2012.28.2.115
- Author:
Jung Min LEE
1
;
Min Ah LEE
;
Hyeon Nam DO
;
Yun Ik SONG
;
Re Ji Na BAE
;
Hye Yeong LEE
;
Sun Hee PARK
;
Jin Seok KANG
;
Jong Koo KANG
Author Information
1. Department of Pathology, Biotoxtech Co., Ltd, Ochang Scientific Industrial Complex, Cheongwon-gun, Korea.
- Publication Type:Original Article
- Keywords:
Crj:CD (SD) rat;
control data;
reference range;
toxicology
- MeSH:
Animals;
Basophils;
Bilirubin;
Body Weight;
Eosinophils;
gamma-Glutamyltransferase;
Humans;
Male;
Organ Size;
Rats;
Reference Values;
Sprains and Strains;
Toxicology;
Urinalysis;
Uterus
- From:Laboratory Animal Research
2012;28(2):115-121
- CountryRepublic of Korea
- Language:English
-
Abstract:
Reference ranges of standard experimental parameters are useful for comparisons in toxicology. The aim of this study was to collect data from 13-week repeated toxicity studies in Crl:CD (SD) rats, a strain widely used for toxicity and efficacy research, for establishing domestic reference values. Data on body weight, food consumption; urinalysis, hematological, and blood biochemical parameters; and organ weights were collected from 11 toxicity studies in 220 Crl:CD (SD) rats (110 males and 110 females). The studies had been performed at a single testing facility over the last 5 years and involved animals sourced from a single breeder. The findings were collated as means, standard deviations, percentages, and ranges. Urine volume, uterus weight, eosinophil, and basophil counts, and triglyceride, total bilirubin, and gamma-glutamyl transpeptidase levels showed standard deviations of 30% or more. These historical control data would help to interpret the effects of test substances in routine toxicity and efficacy studies.
