Anti-hyperlipidemic effect of soybean extract fermented by Bacillus subtilis MORI in db/db mice.
10.5625/lar.2012.28.2.123
- Author:
Yoonyi NAM
1
;
Harry JUNG
;
Sankarapandian KARUPPASAMY
;
Jae Yeon LEE
;
Kyung Don KANG
;
Kyo Yeol HWANG
;
Su Il SEONG
;
Jun Gyo SUH
Author Information
1. Institute of Natural Medicine, Hallym University, Chuncheon, Korea. jgsuh@hallym.ac.kr
- Publication Type:Original Article
- Keywords:
Fermented soybean extract;
Bacillus subtilis MORI;
1-deoxynojirimycin;
lipid-lowering effect;
anti-obesity
- MeSH:
1-Deoxynojirimycin;
Animals;
Bacillus;
Bacillus subtilis;
Body Weight;
Cholesterol;
Cholesterol, LDL;
Humans;
Liver;
Male;
Mice;
Mice, Obese;
Soybeans
- From:Laboratory Animal Research
2012;28(2):123-129
- CountryRepublic of Korea
- Language:English
-
Abstract:
The purpose of this study was to investigate the anti-hyperlipidemic effect of soy bean extract solution fermented by Bacillus subtilis MORI (BTD-1E) in obese db/db mice. Eight-week-old male db/db mice were administered 33.3 mg/kg BTD-1E solution orally once a day for four weeks. The BTD-1E group showed significantly lower body weight compared with the db control group (P<0.05). The BTD-1E group showed significantly lower serum total cholesterol and LDL cholesterol levels compared with the db control group, respectively (P<0.05, P<0.01). The BTD-1E group showed significantly decreased liver weight relative to final body weight compared with the db control group (P<0.01). After four weeks of BTD-1E administration, lipid droplets in the liver were apparently decreased in the BTD-1E group compared to the db control group. In summary, our results suggest that BTD-1E has an anti-hyperlipidemic effect in the obese mouse model.
