Seven cases of toxic encephalopathy associated with diquat poisoning
10.3760/cma.j.issn.1671-0282.2022.12.014
- VernacularTitle:敌草快相关中毒性脑病7例报道
- Author:
Junjun WANG
1
;
Shuai TONG
;
Tangjuan ZHANG
;
Mingke LIU
;
Lu ZHAO
;
Yaohui YANG
;
Xinya JIA
;
Chao LAN
Author Information
1. 郑州大学第一附属医院急诊重症监护病区，郑州 450000
- Keywords:
Diquat,DQ;
Poisoning;
Toxic encephalopathy;
Central nervous system complications;
Epileptiform seizures;
Central pontine myelinolysis, CPM;
Cerebral edema
- From:
Chinese Journal of Emergency Medicine
2022;31(12):1648-1653
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To improve the understanding of the clinical features of toxic encephalopathy associated with diquat poisoning.Methods:This study collected and analyzed the diagnosis and treatment process of 7 patients with acute diquat poisoning combined with central nervous system complications admitted to the First Affiliated Hospital of Zhengzhou University from April 2021 to April 2022. "Diquat" and "Poisoning" were used as keywords to search in CNKI, Wanfang database and PubMed database, and the literature of previous cases was reviewed for summary analysis.Results:Among the 7 patients in our hospital, there were 2 males and 5 females, with an average age of 31 years (range14-57) and an average dose of 23.14 g [(10-40)g]. During the treatment, 3 patients developed irritability and convulsions, 3 patients occurred coma, and one had generalized tonic-clonic seizures. Four patients died and 3 survived, of which 2 patients returned to normal life and study, and one remained abnormal mental behavior (currently in long-term follow-up). All three survivors developed neurological symptoms later than those who died, and were awake about 30 days after taking the drug.Conclusions:Toxic encephalopathy associated with diquat poisoning has rapid progression, poor prognosis and high mortality. This study found that the survival rate of patients with > 48 h of first onset of neurological symptoms is much higher than that of patients with ≤ 48 h of first onset of neurological symptoms, while sex, age, estimated oral dose, and type of presentation of neurological symptoms for the first time have little effect on the survival rate of hospital discharge. The earlier neurological symptoms appear, the greater the likelihood of a poor prognosis.
