Anti-inflammatory effects of Houttuynia cordata supercritical extract in carrageenan-air pouch inflammation model.
10.5625/lar.2012.28.2.137
- Author:
Dajeong KIM
1
;
Dongsun PARK
;
Jangbeen KYUNG
;
Yun Hui YANG
;
Ehn Kyoung CHOI
;
Yoon Bok LEE
;
Hyun Kyu KIM
;
Bang Yeon HWANG
;
Yun Bae KIM
Author Information
1. College of Veterinary Medicine, Chungbuk National University, Cheongju, Korea. solar93@cbu.ac.kr
- Publication Type:Letter
- Keywords:
Carrageenan;
inflammation;
Houttuynia cordata;
supercritical extract
- MeSH:
Administration, Oral;
Animals;
Carrageenan;
Cell Count;
Dexamethasone;
Dinoprostone;
Exudates and Transudates;
Houttuynia;
Indomethacin;
Inflammation;
Injections, Intraperitoneal;
Nitric Oxide;
Rats;
Tumor Necrosis Factor-alpha
- From:Laboratory Animal Research
2012;28(2):137-140
- CountryRepublic of Korea
- Language:English
-
Abstract:
Anti-inflammatory effects of Houttuynia cordata supercritical extract (HSE) were investigated in rat carrageenan-air pouch model. Oral administration of HSE (50-200 mg/kg) suppressed carrageenan-induced exudation and albumin leakage, as well as inflammatory cell infiltration at a high dose (200 mg/kg). Intraperitoneal injection of dexamethasone (2 mg/kg) only decreased exudation and cell infiltration, while indomethacin (2 mg/kg, i.p.) reduced exudate volume and albumin content without influence on the cell number. HSE lowered tumor-necrosis factor-alpha (TNF-alpha) and nitric oxide (NO), as well as prostaglandin E2 (PGE2). Dexamethasone only reduced TNF-alpha and NO, while indomethacin decreased PGE2. The results indicate that HSE exhibits anti-inflammatory effects by inhibiting both TNF-alpha-NO and cyclooxygenase-2-PGE2 pathways.
