Research progress in the mechanism of TCM intervention in anti-tumor effect of A549 cells in human lung adenocarcinoma
10.3760/cma.j.cn115398-20220710-00113
- VernacularTitle:中药干预人肺腺癌A549细胞抗肿瘤作用机制研究进展
- Author:
Chaoyue ZHANG
1
;
Jun XIAO
;
Lin LONG
;
Jinfang SUN
Author Information
1. 山东中医药大学第一临床医学院2020级硕士研究生，济南 250355
- Keywords:
Adenocarcinoma of lung;
A549 cells;
Traditional Chinese Medicine;
Mechanism of action;
Review
- From:
International Journal of Traditional Chinese Medicine
2023;45(7):921-925
- CountryChina
- Language:Chinese
-
Abstract:
Traditional Chinese Medicine (TCM) exerts anti-tumor effects by intervening in A549 cells of human lung adenocarcinoma, mainly including activating or inhibiting downstream target proteins of Bcl-2 and Bax, or forming RIP1/RIP3/MLKL complex bodies by affecting pathways such as PI3K/Akt, thereby inducing apoptosis in A549 cells of lung adenocarcinoma; blocks the cell growth phase, thereby inhibiting the proliferation of lung adenocarcinoma A549 cells; inhibits invasion and metastasis of A549 cells by affecting the MMPs pathway, STAT3 pathway, and regulating epithelial mesenchymal transition related factors; suppresses or activates the expression of related proteins or affect related signaling pathways, thereby reversing the resistance of lung cancer A549/DDP cell lines to cisplatin and paclitaxel.
