Study on medication law of TCM compounds with national patents for treatment of vascular dementia
10.3760/cma.j.cn115398-20220420-00286
- VernacularTitle:基于数据挖掘的中药复方专利治疗血管性痴呆用药规律研究
- Author:
Weiwei JIAO
1
;
Wei SHEN
;
Xiao LIANG
;
Jingjing WEI
;
Min JIA
;
Lin LEI
;
Qian CHEN
;
Xinyun ZENG
;
Yunling ZHANG
;
Yan LU
Author Information
1. 中国中医科学院西苑医院2020级博士研究生，北京 100091
- Keywords:
Dementia, vascular;
TCM compound;
Patents;
Data mining;
Association rules;
Clustering analysis;
Medication law
- From:
International Journal of Traditional Chinese Medicine
2023;45(6):772-776
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the prescription and medication law of Traditional Chinese Medicine (TCM) compounds in the treatment of vascular dementia (VD) based on patent database.Methods:TCM compounds with patents about VD were retrieved from Chinese patent announcement website of the State Intellectual Property Office and CNKI. The retrieval time was from the establishment to the databases to 31 st, March 2022. The frequency, clusteringand association analysis were carried out with the help of TCM inheritance auxiliary platform (V2.5). The medication law was analyzed. Results:154 TCM compound patents for the treatment of vascular dementia were screened, involving 227 kinds of Chinese materia medica. Among them, Acori Tatarinowii Rhizoma (44 times, 28.57%) was used more frequently, and the common medicinal pair was Salviea Miltiorrhizae Radix et Rhizoma- Acori Tatarinowii Rhizoma (17 times, 11.03%). The medicinal property was mainly warm, the taste was mainly sweet, and the meridian was mainly liver meridian. Those with high confidence based on association rules were " Corni Fructus -Acori Tatarinowii Rhizoma" (0.90), " Corni Fructus -Rehmannize Radix et Praeparata" (0.90). Based on the complex network, it was concluded that the core drugs were 14 groups such as " Rehmannize Radix et Praeparata- Cistanches Herba- Corni Fructus". The new prescriptions extracted by entropy cluster analysis included 7 groups such as " Rehmannize Radix et Praeparata, Cistanches Herba, Corni Fructus and Asparagi Radix". Conclusion:The treatment of VD by TCM compounds with national patents is mainly based on tonifying deficiency, promoting blood circulation and removing blood stasis, eliminating phlegm and dampness, expelling wind and dredging collaterals, opening orifices and resuscitation, which can provide reference for clinical practice and new drug research and development.
