A Case of Microscopic Polyangiitis with Peripheral Neuropathy.
- Author:
Jai Won BYUN
1
;
In Hong LEE
;
Ja Hun JUNG
;
Ki Chan KIM
;
Tae Hwan KIM
;
Jae Bum JUN
;
Sung Soo JUNG
;
Sang Cheol BAE
;
Dae Hyun YOO
;
Ho Jung KIM
;
Seong Yoon KIM
Author Information
1. Department of Internal Medicine, College of Medicine, Hanyang University, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
Microscopic polyangiitis;
Peripheral neuropathy;
Glomerulonephritis
- MeSH:
Adrenal Cortex Hormones;
Aged;
Biopsy;
Cyclophosphamide;
Female;
Glomerulonephritis;
Humans;
Microscopic Polyangiitis*;
Peripheral Nervous System Diseases*;
Polyneuropathies;
Prognosis;
Recurrence;
Sural Nerve;
Vasculitis;
Venules
- From:The Journal of the Korean Rheumatism Association
2000;7(2):163-167
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Microscopic polyangiitis (MPA) is a systemic necrotizing vasculitis of small-sized vessels (capillary, venule, or arterioles) whose clinical manifestations are very similar to those of PAN (polyarteritis nodosa), but it is characterized by the presence of rapidly progressive glomerulonephritis (RPGN), which is nearly constant, and pulmonary involvement usually absent in PAN. Peripheral neuropathy occurs in only 14~36% of the patients with MPA, distinctly less frequent than in those with classic PAN. While PAN may be considered a self-limiting disease which tend not to recur once remission is acquired, relapse occurs frequently in MPA. Prognosis has been transformed by corticosteroids and immunosuppressive drugs, especially cyclophosphamide. We reported a 72-year-old woman with subacute sensorimotor polyneuropathy involving peroneal and sural nerve accompanied by focal segmental glomerulonephritis which was proven by renal biopsy.
