Discussion on the pathogenesis of "spleen deficiency and dampness accumulation" of colorectal polyps based on intestinal flora and glucose and lipid metabolism
10.3760/cma.j.cn115398-20221031-00107
- VernacularTitle:基于肠道菌群及糖脂代谢探讨结直肠息肉 “脾虚湿蕴”病机的生物学内涵
- Author:
Zhengyu XU
1
;
Di WU
;
Yichen WANG
;
Qingqing ZHANG
;
Lijiang REN
;
Han WANG
;
Ping WANG
Author Information
1. 北京中医药大学研究生院，北京 100029
- Keywords:
Intestinal polyps;
Intestinal flora;
Glucose and lipid metabolism;
Spleen deficiency and dampness accumulation
- From:
International Journal of Traditional Chinese Medicine
2023;45(5):527-530
- CountryChina
- Language:Chinese
-
Abstract:
Intestinal flora imbalance and abnormal glucose and lipid metabolism are important risk factors and pathological mechanisms of colorectal polyps. "Spleen deficiency and dampness accumulation" is the core pathogenesis of colorectal polyps. The imbalance of intestinal flora is related to spleen deficiency, and the application of Chinese herbs for invigorating spleen is helpful to the recovery of intestinal flora balance. Abnormal glucose and lipid metabolism is related to dampness accumulation, and it is effective to treat it with bitter and spicy herbs or spleen-invigorating and dampness-eliminating herbs. The interaction between intestinal flora imbalance and abnormal glucose and lipid metabolism changes intestinal microenvironment, damages intestinal epithelial cells, causes abnormal proliferation of intestinal stem cells and leads to colorectal polyps, which is consistent with the pathogenesis of spleen deficiency and dampness accumulation in Traditional Chinese Medicine. Thus, we tried to explore the biological connotation of the pathogenesis of "spleen deficiency and dampness accumulation" of colorectal polyps from the perspective of the interaction of intestinal flora and glucose and lipid metabolism, in order to provide reference for identifying high-risk population and analyzing the therapeutic mechanism of compound prescription for invigorating spleen and removing dampness.
