Study on the evolution of TCM syndromes of 171 cases of Kawasaki disease under the intervention of gamma globulin therapy based on factor analysis
10.3760/cma.j.cn115398-20220902-00027
- VernacularTitle:基于因子分析的171例川崎病患儿在丙种球蛋白干预下中医证候演变规律研究
- Author:
Xiangna YANG
1
;
Yuxin HUANG
;
Jiaming LIU
;
Zhuoming LU
;
Yanfei WANG
;
Qina YE
;
Ning LI
;
Fangwei XU
;
Li WANG
;
Jian DENG
Author Information
1. 广州市妇女儿童医疗中心中医儿科，广州 510623
- Keywords:
Mucocutaneous lymph node syndrome;
Kawasaki disease;
Child;
TCM syndromes;
TCM syndrome elements;
Factor analysis;
Gamma globulin;
Wei Qi Ying Xue
- From:
International Journal of Traditional Chinese Medicine
2023;45(2):141-147
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the evolution of Traditional Chinese Medicine (TCM) syndromes of 171 cases of Kawasaki disease (KD) under the intervention of gamma globulin therapy based on factor analysis.Methods:A cross-sectional study. 171 cases of KD children hospitalized in the Department of Cardiology of Guangzhou Women's and Children's Medical Center from July 2019 to December 2020 were collected. All patients were treated with intravenous gamma globulin (2 g/kg) for 1 week. According to the results of the treatment with C-ball, 171 children with C-ball sensitive KD were selected to collect the four diagnostic data, and the representative syndromes of defensive level, qi level, yin level, and nutritive level were observed. Factor analysis was used to analyze the evolution of syndrome in 171 children with KD c-ball sensitivity.Results:The result of factor analysis showed that the KMO statistics of 171 children with c-ball sensitivity before treatment was 0.792, and Bartley test was significant ( P<0.01). 16 common factors were extracted, and 23 syndromes were screened, mainly including defensive level disorder, qi level disorder,nutritive level disorder,yin level disorder, heat stagnation and blood stasis syndrome. One week after treatment, the statistic of KMO test was 0.787, and Bartley test was significant ( P<0.01). 9 common factors were extracted, and 10 syndromes were screened, mainly including qi deficiency syndrome, yin deficiency syndrome and blood stasis syndrome. Conclusion:Before treatment, the TCM syndromes in KD C-cell sensitive children are mainly nutritive level disorder, defensive level disorder, qi level disorder yin level disorder, and heat stagnation and blood stasis syndrome; after treatment, the main TCM syndromes are mainly qi deficiency syndrome, yin deficiency syndrome and blood stasis syndrome.
