Pharmacokinetics effect of 8 components of Baizhu Shaoyao San with processing method based on UPLC-MS/MS
10.3760/cma.j.cn115398-20220513-00194
- VernacularTitle:基于UPLC-MS/MS研究炮制对白术芍药散8种成分药代动力学的影响
- Author:
Kanping SUN
1
;
Xuefen YANG
;
Jingjing LI
;
Ying MENG
;
Junjie JIN
Author Information
1. 淮安市康复医院金湖县人民医院药学部，淮安 211600
- Keywords:
Pharmacokinetic;
Baizhu Shaoyao San;
Tandem mass spectrometry;
Processing (TCD);
Chemical compositions (TCD)
- From:
International Journal of Traditional Chinese Medicine
2023;45(1):60-66
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the pharmacokinetics effect of 8 components of processed Baizhu Shaoyao San on rats.Methods:The rats were divided into processing group and unprocessing group, administered with decoction of Baizhu Shaoyao San by gavage respectively. Then, blood was collected from fundus vein at certain time to obtain the plasma. Finally, the contents of 8 components in plasma were detected and compared by UPLC-MS/MS method, and the methodology of the experiment was tested. The drug concentration in blood and the collection time of blood were analyzed by DAS software, and the time curves of different groups were obtained, the pharmacokinetic parameters were calculated.Results:The blood peak concentration, peak time, area under the drug time curve, and average residence time of 8 components in the serum of rats in the raw product group and the fried product group were different to varying degrees.Conclusion:Processed Baizhu Shaoyao San could influence the behavior of the components measured in rats, which may affect the clinical therapeutic effect of Baizhu Shaoyao San.
