Research progress of solute carriers related genes in malignant tumors
10.3760/cma.j.cn371439-20230305-00056
- VernacularTitle:溶质载体SLC7A5及SLC7A11基因在恶性肿瘤中的研究进展
- Author:
Bohan LIU
1
;
Junxing HUANG
Author Information
1. 南京医科大学附属泰州市人民医院肿瘤科，泰州 225300；大连医科大学临床医学系，大连 116000
- Keywords:
Solute carrier proteins;
Neoplasms;
Gene expression;
Molecular biology;
Molecular targeted therapy
- From:
Journal of International Oncology
2023;50(5):280-284
- CountryChina
- Language:Chinese
-
Abstract:
As a transport channel for amino acids, solute carrier (SLC) exists in all kinds of cells, and its function is to transport various amino acids and provide necessary nutrients for the growth and development of cells. In recent years, SLC7A5 and SLC7A11 genes of SLC7 family members have been found to be highly expressed in various malignant tumors, which can promote the occurrence and development of tumors by providing necessary amino acids for tumors. Studies have shown that these genes are associated with a variety of malignant tumors, and their expression is closely related to the growth, metastasis, treatment and prognosis of tumor cells. Moreover, the results of multiple studies suggest that SLC7A5 and SLC7A11 genes can be used as therapeutic targets for malignant tumors. Clarifying the expression and clinical significance of the above genes in malignant tumors, the molecular biological mechanism and the progress of molecular targeted therapy are helpful to provide a new way for the diagnosis and treatment of malignant tumors.
