Role of E2F1 and lncRNAs in the development of malignant tumors

VernacularTitle:E2F1与lncRNA在恶性肿瘤发生发展中的作用
Author: Ying BAI ¹ ; Qi LI ; Yaqin LI ; Weihong ZHAO
Author Information

1. 山西医科大学第二临床医学院，太原　030001
Keywords: Neoplasms; RNA, long noncoding; E2F1 transcription factor
From: Journal of International Oncology 2023;50(3):164-168
CountryChina
Language:Chinese
Abstract: E2F1, a nucleoprotein gene belongs to transcription factor, is closely associated with the development of malignant tumours. Long non-coding RNAs (lncRNAs) are aberrantly expressed in a variety of tumors. In studies of molecular mechanisms associated with lncRNAs and tumours, E2F1 has been identified as a key factor that can play a critical role as an upstream regulator or downstream target of lncRNAs, and even inter-regulate to form a positive feedback loop. This paper reviews the significance of the interaction between E2F1 and lncRNA in malignant tumors in recent years, and aims to provide ideas for the study of tumor mechanisms.