Clinical application of PARP inhibitors in breast cancer
10.3760/cma.j.cn371439-20221023-00019
- VernacularTitle:PARP抑制剂在乳腺癌中的临床应用
- Author:
Lixi LI
1
;
Di ZHANG
;
Yang LUO
;
Fei MA
Author Information
1. 国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院内科，北京 100021
- Keywords:
Breast neoplasms;
PARP inhibitors;
Biomarkers, tumor;
Clinical trial
- From:
Journal of International Oncology
2023;50(2):91-96
- CountryChina
- Language:Chinese
-
Abstract:
Poly adenosine diphosphate ribose polymerase (PARP) inhibitors lead to synthetic lethality in homologous recombination repair-deficient (HRD) tumors by inhibiting DNA damage repair. Two PARP inhibitors, olaparib and talazoparib, have been approved for the salvage treatment of breast cancer susceptibility gene (BRCA) mutation, human epidermal growth factor receptor 2 (HER2) negative advanced breast cancer, and adjuvant treatment of early breast cancer. PAPR inhibitor single agent shows good antitumor activity and controllable safety. A number of clinical studies on PAPR inhibitors combined with chemotherapy, radiotherapy, antiangiogenic therapy and immunotherapy are being carried out. The indications of PARP inhibitors also extend from BRCA mutation to HRD, from ovarian cancer and breast cancer to other solid tumors, promising to benefit more patients in the future.
