Lumican and tumor therapy resistance

VernacularTitle:Lumican与肿瘤治疗抵抗
Author: Ge HU ¹ ; Fan XIA ; Xueya WU ; Yun WANG ; Xiuli XU
Author Information

1. 中国科学院合肥肿瘤医院综合四科，合肥　230000
Keywords: Neoplasms; Lumican; Therapy resistance
From: Journal of International Oncology 2023;50(2):87-90
CountryChina
Language:Chinese
Abstract: Lumican is a member of the small leucine-rich proteoglycan family, which is involved in cell processes related to tumorigenesis and development, such as epithelial-mesenchymal transition, cell proliferation, migration, invasion and adhesion. The expression of Lumican in different tumors is positively or negatively correlated with tumor progression, and can be used as a reference for tumor prognosis and efficacy evaluation. Further study of the correlation and potential mechanism between Lumican and tumor therapy resistance can provide new ideas for predicting clinical therapeutic efficacy.