Study progression on mechanism of long non-coding RNAs regulating drug resistance in osteosarcoma
10.3760/cma.j.cn371439-20221005-00010
- VernacularTitle:长非编码RNA调控骨肉瘤耐药机制的研究进展
- Author:
Xiaoping MA
1
;
Junli CHANG
;
Xingyuan SUN
;
Yanping YANG
Author Information
1. 上海中医药大学附属龙华医院脊柱病研究所 教育部筋骨理论与治法重点实验室，上海 200032
- Keywords:
RNA, long non-coding;
Osteosarcoma;
Drug resistance, neoplasms
- From:
Journal of International Oncology
2023;50(1):51-54
- CountryChina
- Language:Chinese
-
Abstract:
Osteosarcoma is the most common primary solid bone malignancy. The main factor leading to recurrence and metastasis of osteosarcoma is resistance to chemotherapy drugs. Long non-coding RNAs can affect drug resistance in osteosarcoma by regulating epithelial-mesenchymal transition, cell autophagy, apoptosis, drug efflux, and cell cycle, suggesting that long non-coding RNAs may become new targets for drug resistance in osteosarcoma treatment.
