Research progress in reversing multidrug resistance in colorectal cancer
10.3760/cma.j.cn371439-20220614-00008
- VernacularTitle:结直肠癌多药耐药逆转的研究进展
- Author:
Xi WANG
1
;
Chuanqing WU
Author Information
1. 华中科技大学同济医学院附属协和医院胃肠外科，武汉 430022
- Keywords:
Colorectal neoplasms;
Drug resistance, neoplasm
- From:
Journal of International Oncology
2023;50(1):42-46
- CountryChina
- Language:Chinese
-
Abstract:
Multidrug resistance impacts negatively upon the curative effect of chemotherapy and prognosis in colorectal cancer. There is a growing body of studies trying to develop drugs to overcome multidrug resistance against its common targets, including ATP-binding cassette proteins, metabolic enzymes, apoptotic genes, signaling pathways and genetic material, among which P-glycoprotein inhibitors and drugs disrupting DNA are deeply developed. Developing new inhibitors or combining existing inhibitors with conventional treatment are hopeful ways to overcome multidrug resistance in colorectal cancer.
